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CAS No.: 2086-83-1
Synonyms: Natural Yellow 18;黄连素;小檗碱
Berberine is an isoquinoline alkaloid isolated from the herb of Coptis chinensis Franch with anti-inflammatory and anti-diabetic effects.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT03097965 | Obesity | Not Applicable | Completed | - | - |
NCT03728244 | Graft Pain Gi... more >>ngival Recession Collapse << | Phase 1 Phase 2 | Not yet recruiting | August 2020 | - |
NCT02737943 | Burns | Phase 1 | Recruiting | January 2018 | Egypt ... more >> Zagazig University Hospitals Recruiting Zagazig, Alsharkia, Egypt, 44519 Contact: Mohammad S Alsabbahi, As. Lecturer +201092007426 doctor.sabbahi@gmail.com Principal Investigator: Mohammad S Alsabbahi, As. Lecturer Sub-Investigator: Mohamed HA Elsayed, As. Lecturer Sub-Investigator: Mohamed AM Ebrahim, As. Lecturer Sub-Investigator: Sameh M Hassan, Intern Sub-Investigator: Mohamed H Abdelhady, Student Sub-Investigator: Mohamed A Salama, Student Collapse << |
实验方案
技术信息
CAS号 | 2086-83-1 | 储存条件 |
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分子式 | C20H18NO4 | 运输 | 蓝冰 | |||||
分子量 | 336.36 | 别名 | Natural Yellow 18;黄连素;小檗碱 | |||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT03097965 | Obesity | Not Applicable | Completed | - | - |
NCT03728244 | Graft Pain Gi... more >>ngival Recession Collapse << | Phase 1 Phase 2 | Not yet recruiting | August 2020 | - |
NCT02737943 | Burns | Phase 1 | Recruiting | January 2018 | Egypt ... more >> Zagazig University Hospitals Recruiting Zagazig, Alsharkia, Egypt, 44519 Contact: Mohammad S Alsabbahi, As. Lecturer +201092007426 doctor.sabbahi@gmail.com Principal Investigator: Mohammad S Alsabbahi, As. Lecturer Sub-Investigator: Mohamed HA Elsayed, As. Lecturer Sub-Investigator: Mohamed AM Ebrahim, As. Lecturer Sub-Investigator: Sameh M Hassan, Intern Sub-Investigator: Mohamed H Abdelhady, Student Sub-Investigator: Mohamed A Salama, Student Collapse << |
NCT03221894 | - | - | Recruiting | September 2017 | China ... more >> Dongzhimen Hospital Recruiting Beijing, China Contact: Jing Shi, M.D. 86-10-84013132 shijing87@hotmail.com Collapse << |
NCT03388762 | Prediabetic State | Not Applicable | Recruiting | September 2019 | United States, Maryland ... more >> University of Maryland Center for Diabetes and Endocrinology Recruiting Baltimore, Maryland, United States, 21201 Contact: Kashif Munir, MD 443-682-6800 kmunir@medicine.umaryland.edu University of Maryland Family Medicine Associates Recruiting Baltimore, Maryland, United States, 21201 Contact: Mary Bahr-Robertson 410-706-6155 mbahr@som.umaryland.edu University of Maryland School of Medicine, Department of Family and Community Medicine, East Hall Not yet recruiting Baltimore, Maryland, United States, 21201 Contact: Mary Bahr-Robertson 410-706-6155 mbahr@som.umaryland.edu United States, Ohio Alliance Integrative Medicine Recruiting Cincinnati, Ohio, United States, 45236 Contact: Lisa Gallagher, ND 513-791-5521 lisa.gallagher@myhealingpartner.com Collapse << |
NCT03216811 | Hypercholesterolemia | Phase 2 | Completed | - | Italy ... more >> University Hospital of Ferrara Cona, Ferrara, Italy, 44124 Collapse << |
NCT02898805 | Cardiovascular Risk Factors | Not Applicable | Recruiting | January 2018 | Italy ... more >> Federico II University Recruiting Naples, Italy, 80131 Contact: Raffaele Izzo, Professor +39 081 746 2211 rafizzo@unina.it Collapse << |
NCT02969070 | Hypercholesterolemia ... more >> Endothelial Dysfunction Collapse << | Phase 3 | Unknown | March 2017 | Italy ... more >> University of Naples "Federico II" Recruiting Naples, Italy, 80131 Contact: Giuseppe Giugliano, MD, PhD +390817462240 giuseppe.giugliano@unina.it Sub-Investigator: Raffaele Izzo, MD Sub-Investigator: Maurizio Galderisi, MD Sub-Investigator: Giuseppe Giugliano, MD, PhD Collapse << |
NCT03420976 | Small Intestinal Bacterial Ove... more >>rgrowth Collapse << | Phase 1 Phase 2 | Recruiting | February 1, 2019 | United States, Ohio ... more >> Good Medicine Recruiting Oxford, Ohio, United States, 45056 Contact: Carman Clark 513-273-9944 ccclark@thisisgoodmedicine.com Principal Investigator: Dr. Nathan Morris, MD Collapse << |
NCT03772262 | Interaction Drug Food | Early Phase 1 | Recruiting | March 31, 2019 | United States, Washington ... more >> Washington State University Recruiting Spokane, Washington, United States, 99202 Contact: Malathi Jandhyala 509-335-3668 irb@wsu.edu Collapse << |
NCT03027336 | Dyslipidemias | Phase 2 | Completed | - | Italy ... more >> Endocrinology Unit Parma, Italy, 43126 Collapse << |
NCT01649986 | Hyperlipidemia | Phase 4 | Unknown | December 2017 | Italy ... more >> Sapienza University Recruiting Rome, Italy, 00166 Contact: Francesco Pelliccia, MD +39064997 ext 123 f.pelliccia@mclink.it Principal Investigator: Francesco Pelliccia, MD Collapse << |
NCT02001883 | Coronary Artery Disease | Phase 4 | Unknown | December 2015 | Italy ... more >> University Sapienza Recruiting Rome, Please Select, Italy, 00161 Contact: FRANCESCO PELLICCIA f.pelliccia@mclink.it Collapse << |
NCT01562080 | Hyperlipidemia ... more >> Low-density-lipoprotein-type Elevated Triglycerides Collapse << | Phase 2 Phase 3 | Completed | - | Spain ... more >> Hosp. Universitario San Joan Reus, Tarragona, Spain Collapse << |
NCT02422927 | Atherosclerosis ... more >> Inflammation Hypercholesterolemia Collapse << | Phase 4 | Completed | - | - |
NCT00654459 | - | - | Completed | - | Italy ... more >> Department of internal medicine University Federico II Naples, Italy, 80131 Collapse << |
NCT01490229 | Coronary Artery Disease | Phase 4 | Unknown | December 2016 | Italy ... more >> San Raffaele Pisana Recruiting Rome, Italy, 00100 Contact: Giuseppe Marazzi, MD +39 335 8381320 giuseppe.marazzi@yahoo.com Collapse << |
NCT01293162 | - | - | Completed | - | Italy ... more >> Ambulatorio Ipertensione e Unità Coronarica Federico II University Napoli, Italy, 80131 Collapse << |
NCT02295176 | Metabolic Syndrome ... more >> Insulin-resistance Left Ventricular Hypertrophy Collapse << | Not Applicable | Completed | - | Italy ... more >> Domenico Bonaduce Naples, Italy, 80131 Ferruccio Galletti Naples, Italy Giuseppe Schillaci Terni, Italy Collapse << |
NCT02834078 | Pre Diabetes | Not Applicable | Completed | - | - |
NCT03470376 | Hypercholesterolemia ... more >> Inflammation Atherosclerosis Collapse << | Phase 4 | Completed | - | - |
NCT03019263 | Dyslipidemia | Not Applicable | Completed | - | Italy ... more >> Fondazione IRCCS Policlinico San Matteo Pavia, Italy, 27100 Collapse << |
NCT01087632 | Metabolic Syndrome | Not Applicable | Completed | - | Italy ... more >> Federico II University - Department of Internal Medicine Naples, Italy Collapse << |
NCT01696448 | Metabolic Syndrome | Not Applicable | Completed | - | United States, Georgia ... more >> Atlanta Vascular Research Foundation Atlanta, Georgia, United States, 30342 Collapse << |
NCT03609892 | Gastric Ulcer ... more >> Chronic Gastritis Gastric Cancer Helicobacter Pylori Infection Gastritis Collapse << | Phase 4 | Recruiting | April 1, 2019 | China, Shaanxi ... more >> Xijing Hosipital of Digestive Disease Recruiting Xi`an, Shaanxi, China, 710032 Contact: Yongquan Shi, professor 86-029-84771515 shiyquan@fmmu.edu.cn Collapse << |
NCT00462046 | Diabetes Mellitus, Type 2 ... more >> Metabolic Syndrome Collapse << | Phase 3 | Completed | - | - |
NCT00425009 | Type 2 Diabetes | Phase 1 Phase 2 | Completed | - | China ... more >> Department of Endocrinology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai, China, 200092 Collapse << |
NCT00633282 | Nonalcoholic Fatty Liver Disea... more >>se Collapse << | Phase 2 | Completed | - | China, Shanghai ... more >> Endocrinology and Metabolism Department, Zhongshan Hospital, Fudan University, Shanghai, Shanghai, China, 200032 Department of Endocrinology and Metabolism,Shanghai Clinical Center of Diabetes,Shanghai Institute of Diabetes,The sixth people's Hospital Affiliated to Shanghai Jiaotong University Shanghai, Shanghai, China, 200233 Department of Endocrinology and Metabolism,The Fifth People's Hospital,Fudan University Shanghai, Shanghai, China, 200240 Collapse << |
NCT01116167 | Polycystic Ovary Syndrome | Not Applicable | Unknown | December 2013 | China, Anhui ... more >> Affiliated Hospital of Anhui University of Chinese Medicine Active, not recruiting Hefei, Anhui, China China, Guangdong Affiliated Hospital of Guangzhou Medical University Active, not recruiting Guangzhou, Guangdong, China Guangzhou Medical School First Affiliated Hospital Recruiting Guangzhou, Guangdong, China Principal Investigator: Hongxia Ma, MD China, Heilongjiang Daqing LongNa Hospital Active, not recruiting Daqing, Heilongjiang, China, 163000 Daqing Longnan hospital Active, not recruiting Daqing, Heilongjiang, China Obstetrics and Gynecology,Heilongjiang University of Chinese Medicine Recruiting Harbin, Heilongjiang, China, 150040 Contact: Xiaoke Wu, MD.PhD. 86-451-8213 0094 xiaokewu2002@vip.sina.com Contact: Lihui Hou, MD. 86-451-8213 0094 houlihui2007@sina.com Principal Investigator: Lihui Hou, MD. Principal Investigator: Xiaoke Wu, MD.PhD. First Affliated Hospital of Harbin Medical University Active, not recruiting Harbin, Heilongjiang, China Mudanjiang maternal and children hospital Active, not recruiting Mudanjiang, Heilongjiang, China China, Henan 2nd Affiliated Hospital of Henan University of Chinese Medicine Active, not recruiting Zhengzhou, Henan, China China, Hunan First Affiliated Hospital of Hunan University of Chinese Active, not recruiting Changsha, Hunan, China China, Jiangsu SuqianMaternal and Child Health Hospital Active, not recruiting Suqian, Jiangsu, China China, Jiangxi First Hospital, Jiangxi college of Chinese Medicine Active, not recruiting Nanchang, Jiangxi, China China, Liaoning Dalian Maternal and Child Health Hospital Active, not recruiting Dalian, Liaoning, China China, Shanxi Shanxi Hospital of Chinese Medicine Active, not recruiting Taiyuan, Shanxi, China China, Tianjin First Affiliated Hospital of Tianjin University of Chinese Medicine Active, not recruiting Tianjin, Tianjin, China Second Affiliated Hospital, Tianjin University of Chinese Medicine Active, not recruiting Tianjin, Tianjin, China China, Zhejiang Zhejiang province hospital of integrated traditional and western medicine Active, not recruiting Hangzhou, Zhejiang, China China Second Affiliated Hospital of Heilongjiang University of Chinese Medicine Active, not recruiting Harbin, China Collapse << |
NCT02078167 | Hypercholesterolemia | Phase 4 | Completed | - | - |
NCT02548832 | Mixed Dyslipidemia | Phase 2 | Unknown | July 2016 | Mexico ... more >> Institute of Experimental and Clinical Therapeutics (INTEC), CUCS, University of Guadalajara Recruiting Guadalajara, Jalisco, Mexico, 44340 Contact: Esperanza Martínez Abundis, PhD Science (33) 1058-5200 ext 34211 esperanzamartnezabundi@yahoo.com Collapse << |
NCT01138930 | Polycystic Ovary Syndrome ... more >> Obesity Collapse << | Not Applicable | Unknown | June 2013 | China, Guangdong ... more >> Affiliated Hospital of Guangzhou Medical University Recruiting Guangzhou, Guangdong, China Contact: Hongxia Ma, MD Principal Investigator: Hongxia Ma, MD China, Heilongjiang First Affliated Hospital of Harbin Medical University Recruiting Harbin, Heilongjiang, China, 150001 Contact: Zhuoran Wang, MD Principal Investigator: Zhuoran Wang, MD Forth Affiliated Hospital of Harbin Medcal University Recruiting Harbin, Heilongjiang, China, 150001 Contact: Shiyu Han, MD Principal Investigator: Shiyu Han, MD Department of Obstetrics and Gynecology,First Affliated Hospital,Heilongjiang University of Chinese Medicine . Recruiting Harbin, Heilongjiang, China, 150040 Contact: Xiaoke Wu, MD.PhD. 86-451-8213 0094 xiaokewu2002@vip.sina.com Collapse << |
NCT02296021 | Gastritis Pep... more >>tic Ulcer Dyspepsia Collapse << | Phase 4 | Completed | - | China, Shanxi ... more >> Xijing Hospital of Digestive Diseases Xi'an, Shanxi, China, 710032 Collapse << |
NCT02633930 | Gastritis Pep... more >>tic Ulcer Dyspepsia Collapse << | Phase 4 | Completed | - | China, Shanxi ... more >> Xijing Hospital of Digestive Diseases Xi'an, Shanxi, China, 710032 Xijing Hospital of Digestive Disease Xi'an, Shanxi, China, 710032 Collapse << |
NCT02936414 | Schizophrenia | Not Applicable | Completed | - | China, Tianjin ... more >> Tianjin Anding Hospital Tianjin, Tianjin, China, 300222 Collapse << |
NCT02084004 | Type 2 Diabetes Mellitus | Phase 2 Phase 3 | Withdrawn(The sponsor have not... more >> enough money to support this trial) Collapse << | April 2018 | China, Shaanxi ... more >> Second Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China, 710004 The 323rd Hospital of People's Liberation Army Xi'an, Shaanxi, China, 710054 First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China, 710061 Shaanxi Provincial People's Hospital Xi'an, Shaanxi, China, 710068 Collapse << |
NCT03198572 | Non-alcoholic Steatohepatitis | Phase 4 | Not yet recruiting | July 2020 | China, Shanghai ... more >> Department of Endocrinology and Metabolism,Shanghai 6th People's Hospital Shanghai, Shanghai, China China The Affiliated Hospital of Hangzhou Normal University Not yet recruiting Hangzhou, China Contact: Jun-Ping Shi Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Not yet recruiting Shanghai, China Contact: Lun-Gen Lu Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Not yet recruiting Shanghai, China Contact: Jian-Gao Fan Tianjin Third Central Hospital Not yet recruiting Tianjin, China Contact: Fu-Sheng Di Xinjiang Medical University Not yet recruiting Urumqi, China Contact: Fang-Ping He Collapse << |
NCT02983188 | Schizophrenia ... more >> Schizophrenia Spectrum and Other Psychotic Disorders Metabolic Syndrome x Collapse << | Phase 2 Phase 3 | Recruiting | October 2020 | Hong Kong ... more >> Castle Peak Hospital - The Department of General Adult Psychiatry Recruiting Tuen Mun, Hong Kong Contact: Wing-Him, Elvis LAI, MBBS +852 2456 7272 lwh041@ha.org.hk Sub-Investigator: Wing-Him, Elvis LAI, MBBS Collapse << |
NCT02082756 | Prediabetes | Phase 2 Phase 3 | Withdrawn(The sponsor have not... more >> enough money to support this trial) Collapse << | April 2018 | China, Shaanxi ... more >> First Affiliated Hospital of Xi'an Jiaotong University Xi'an,, Shaanxi, China, 710061 Second Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China, 710004 The 323rd Hospital of People's Liberation Army Xi'an, Shaanxi, China, 710054 Shaanxi Provincial People's Hospital Xi'an, Shaanxi, China, 710068 Collapse << |
NCT02808351 | Diabetes Mellitus ... more >> Chronic Kidney Disease Collapse << | Phase 4 | Recruiting | August 2020 | China, Jiangsu ... more >> Nanjing First Hospital Recruiting Nanjing, Jiangsu, China, 210006 Contact: Shaoliang Chen, PhD +86-025-52271351 chmengx@126.com Contact: Jing Kan, MPH +86-025-52271398 kanjingok@126.com Sub-Investigator: Xiaobo Li, PhD Collapse << |
NCT03330184 | Berberine Hydrochloride | Phase 3 | Completed | - | China, Shaanxi ... more >> First Affiliated Hospital of Xi'an Jiaotong University Xi'an,, Shaanxi, China, 710061 Second Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China, 710004 Shaanxi Provincial People's Hospital Xi'an, Shaanxi, China, 710068 Collapse << |
NCT02962245 | Ulcerative Colitis | Phase 4 | Unknown | - | - |
NCT02365480 | Ulcerative Colitis | Phase 1 | Active, not recruiting | - | United States, Illinois ... more >> Northwestern University Chicago, Illinois, United States, 60611 China, Shaanxi Fourth Military Medical University Xi'an, Shaanxi, China, 710032 Collapse << |
NCT03770325 | Cardiovascular Risk Factor | Phase 2 Phase 3 | Not yet recruiting | June 2020 | - |
NCT03378934 | Coronary Artery Disease ... more >> Percutaneous Coronary Intervention Collapse << | Phase 4 | Recruiting | April 2020 | China, Beijing ... more >> Peking Union Medical College Hospital Recruiting Beijing, Beijing, China, 100730 Contact: Zhenyu Liu, M.D. +861069155068 pumch_lzy@163.com Contact: Lihong Xu, B.N. +861069155068 xulihong1990@163.com Collapse << |
NCT02226185 | Colorectal Adenoma | Phase 2 Phase 3 | Active, not recruiting | June 2019 | China ... more >> Shanghai Institute of Digestive Disease Shanghai, China, 200001 Collapse << |
NCT01697735 | Dyslipidemias | Phase 4 | Terminated(Because of lack of ... more >>participants and funds) Collapse << | - | China, Zhejiang ... more >> Second Hospital of Wenzhou Medical College Wenzhou, Zhejiang, China, 325000 Collapse << |
NCT03029390 | Prediabetes I... more >>mpaired Fasting Glucose Impaired Glucose Tolerance Collapse << | Phase 4 | Active, not recruiting | May 2018 | Mexico ... more >> Instituto de Terapeútica Experimental y Clínica. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara Guadalajara, Jalisco, Mexico, 44340 Collapse << |
NCT02861261 | Type 2 Diabetes | Phase 3 | Active, not recruiting | August 2018 | China, Shanghai ... more >> Ruijin hospital,Shanghai Jiao Tong University School of Medicine Shanghai, Shanghai, China Collapse << |
NCT03333265 | Colorectal Adenomas | Phase 2 Phase 3 | Recruiting | December 31, 2020 | China, Shaanxi ... more >> Xijing Hospital of Digestive Disease Recruiting Xi'an, Shaanxi, China, 710032 Contact: xiaohua li, MD, PH.D 13474299901 lixiaohua1982@fmmu.edu.cn Contact: ying zhang, MD, PH.D 13310980140 Collapse << |
NCT03486496 | Lung Adenocarcinoma ... more >> EGFR Mutation Collapse << | Phase 2 | Not yet recruiting | February 1, 2020 | China, Fujian ... more >> Fujian cancer hospital Fuzhou, Fujian, China Collapse << |
NCT03438292 | Healthy | Not Applicable | Recruiting | February 2019 | United States, Florida ... more >> Food Science and human nutrition department at University of Florida Recruiting Gainesville, Florida, United States, 32611 Collapse << |
NCT03708549 | Schizophrenia ... more >> Metabolic Syndrome Berberine Metformin Collapse << | Phase 4 | Recruiting | December 1, 2019 | China, Tianjin ... more >> Tianjin Anding Hospital Recruiting Tianjin, Tianjin, China, 300222 Contact: Jie Li, Doctor +86 022 88188006 tjlijie3827@163.com Collapse << |
NCT02806999 | Hyperglycemia | Phase 4 | Unknown | July 2017 | China, Guangdong ... more >> Guangdong Cardiovascular Insititution, Guangdong General Hospital, Guangdong Academy of Medical Science Not yet recruiting Guangzhou, Guangdong, China, 510085 Contact: Jian Zhuang, M.D. 86-13602884548 drzhuangjian5413@163.com Contact: Chengbin Zhou, M.D. 86-13822182178 zcbwwww@163.com Principal Investigator: Haiyun Yuan, M.D. Collapse << |
NCT03281096 | Colorectal Adenomas | Phase 2 Phase 3 | Recruiting | March 1, 2021 | China, Shaanxi ... more >> Xijing Hospital of Digestive Disease Recruiting Xi'an, Shaanxi, China, 710032 Contact: xiaohua li, MD, PH.D 13474299901 lixiaohua1982@fmmu.edu.cn Contact: ying zhang, MD, PH.D 13310980140 Collapse << |
NCT03251716 | Metabolic Syndrome ... more >> Female Schizophrenia Collapse << | Not Applicable | Completed | - | China, Tianjin ... more >> Tianjin Anding Hospital Tianjin, Tianjin, China, 300222 Collapse << |
NCT03548155 | Schizophrenia ... more >> Therapeutics Collapse << | Phase 4 | Completed | - | - |
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